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KMID : 0386419990120041003
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Journal of the Korean Fracture Society
1999 Volume.12 No. 4 p.1003 ~ p.1011
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New bone Formation in Vascularized Periosteal Flap over the Bone Defect of the Shaft fo the Radius in Rabbit
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Yum Jae-Kwang
Kim Mi-Kyung
Choi Ho-Rim
Yoo Tae-Yeul
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Abstract
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Vascularized periosteal flap(VPF) it thought to enable formation of new bone and promoteunion in bone defect without risk of complications in donor site. Studiol about the VPF thus farhave been centered on the long term result than early change after YPF. The purpose of thisstudy was to elucidate the process of new bone formation in early stage after YPF byradiological, histological, electron microscopical and immunohistochemical studies. In experimental group, segmental resection of bone including the periosteum was performedin fifty-six radii of immature New Zealand white rabbits preserving the periosteal circulationfrom median artery which is the main source of blood supply to the periosteum. In order tosimulate the transplantation of VPF, the vascular pedicle of median artery and veins wasdissected from adjacent soft tissue and the periosteum was longitudinally incised to remove thebone tissue in the periosteum. Thereafter the vascularized periosteum was repaired. From thefirst to fourteenth day after the simulated VPF, the findings in the VPFs were observed byradiological, light microscopical, scanning electron microscopical methods and activity ofosteocalcin was measured by immunohistochemical method. In control group, the bone tissueand periosteum were completely removed from the mid-shaft of seven radii, thereafter theradiological findings were observed at 1, 2, 3, 4, 8, 12, 16th week and light microscopicalfindings were observed at 8, 16th week after operation. From the results of this study, it is concluded that YPF is vigorously and uniformly osteogenicin its early stage. It it thought that this study could serve as a basic data for the futureexperimental studiol about VPF in animals and clinical application.
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KEYWORD
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Long bone shaft, Bone Defect, Vascularized Periosteal Flap, Early Radiological and Histological Findings, Rabbit
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